反应详情

Under exclusion of air, 354 mg (2.88 mmol) 4-methoxyaniline and 13 mg lithium iodide are added to 300 mg (0.96 mmol) 7-acetamino-1-chloro-4-(4-pyridylmethyl)phthalazine in 3.9 ml 1-butanol and heated to boiling for 20 h. After cooling, the dark suspension is filtered off, washed with 1-butanol and ethanol, and dried to obtain title compound: m.p.: 160-163° C.; HPLC: tRet(Grad5-40)=9.5; FAB MS (M+H)+=400.

1. temperatureheated
2. temperatureAfter cooling
3. filtrationthe dark suspension is filtered off
4. washwashed with 1-butanol and ethanol
5. customdried