Trifluoroacetic acid → HCID 22318020, compound

HRID 498751Notes

Reaction equation

HRID 498751 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([Cl:14])[C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[NH:19][C:20](=[O:40])[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]2[CH:35]=[CH:34][N:33]=[C:32]([CH2:36][CH:37]([CH3:39])[CH3:38])[CH:31]=2)[CH:25]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:14][C:12]1[C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]2[NH:19][C:20](=[O:40])[CH2:21][C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30]4[CH:35]=[CH:34][N:33]=[C:32]([CH2:36][CH:37]([CH3:39])[CH3:38])[CH:31]=4)[CH:25]=3)=[N:7][C:8]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589435HCID 86589435, compound

Product 1

HCID 22318020HCID 22318020, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (5-chloro-2-{3-[3-(2-isobutyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M255) (0.31 g, 0.53 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained a light yellow solid (220 mg, 89%).

Sources & evidence

ORD record
ord-b7628c9993164e41bc1c2e9d19460496
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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