HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 11212447, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 86589439 | HCID 86589439 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11212447 | HCID 11212447 | — |
Reaction Steps
The title compound was prepared from (RS)-[5-methyl-2-(3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M260) (6.20 g, 98.8 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light brown solid (2.74 g, 65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-fa4965c5b73f4f3f8952a0e5be6f2e73 |
| Source note | uspto-grants-2005_09 |