Trifluoroacetic acid → HCID 11212447, compound

HRID 498756Notes

Reaction equation

HRID 498756 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[NH:19][C:20](=[O:44])[CH2:21][C:22](=O)[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]2[CH:34]=[CH:33][N:32]=[C:31]([CH2:35][O:36]C3CCCCO3)[CH:30]=2)[CH:24]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:36][CH2:35][C:31]1[CH:30]=[C:29]([C:25]2[CH:24]=[C:23]([C:22]3[CH2:21][C:20](=[O:44])[NH:19][C:9]4[CH:10]=[C:11]([C:15]([F:16])([F:17])[F:18])[C:12]([CH3:14])=[CH:13][C:8]=4[N:7]=3)[CH:28]=[CH:27][CH:26]=2)[CH:34]=[CH:33][N:32]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589439HCID 86589439, compound

Product 1

HCID 11212447HCID 11212447, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (RS)-[5-methyl-2-(3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M260) (6.20 g, 98.8 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light brown solid (2.74 g, 65%).

Sources & evidence

ORD record
ord-fa4965c5b73f4f3f8952a0e5be6f2e73
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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