Trifluoroacetic acid → HCID 22318032, compound

HRID 498760Notes

Reaction equation

HRID 498760 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:46])[CH2:23][C:24](=O)[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]2[CH:36]=[CH:35][N:34]=[C:33]([CH2:37][O:38]C3CCCCO3)[CH:32]=2)[CH:26]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:38][CH2:37][C:33]1[CH:32]=[C:31]([C:27]2[CH:26]=[C:25]([C:24]3[CH2:23][C:22](=[O:46])[NH:21][C:9]4[CH:10]=[C:11]([C:17]([F:19])([F:18])[F:20])[C:12]([O:14][CH2:15][CH3:16])=[CH:13][C:8]=4[N:7]=3)[CH:30]=[CH:29][CH:28]=2)[CH:36]=[CH:35][N:34]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589442HCID 86589442, compound

Product 1

HCID 22318032HCID 22318032, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (RS)-[5-ethoxy-2-(3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M263) (0.48 g, 0.73 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (270 mg, 81%).

Sources & evidence

ORD record
ord-4e9419725af043128c02816fcb7348ef
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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