HCID 69486625, compound → HCID 22317736, compound

HRID 498800Notes

Reaction equation

HRID 498800 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([Cl:15])=[CH:10][C:9]=1[NH2:16])(C)(C)C.C(O[C:23](=[O:40])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[CH:38]=[C:37]([NH2:39])[N:36]=[CH:35][N:34]=2)[CH:28]=1)=O)(C)(C)C>>[NH2:39][C:37]1[N:36]=[CH:35][N:34]=[C:33]([C:29]2[CH:28]=[C:27]([C:25]3[CH2:24][C:23](=[O:40])[NH:16][C:9]4[CH:10]=[C:11]([Cl:15])[C:12]([CH3:14])=[CH:13][C:8]=4[N:7]=3)[CH:32]=[CH:31][CH:30]=2)[CH:38]=1

Participants

3

Reactant 2

HCID 69486625HCID 69486625, compoundHCID 69486983tert-Butyl (2-amino-4-chloro-5-methylphenyl)carbamate

Product 1

HCID 22317736HCID 22317736, compound

Procedure

The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic acid tert-butyl ester (Example J22) (103 mg, 0.4 mmol) and 3-[3-(6-amino-pyrimidin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K53) (138 mg, 0.44 mmol) according to the general procedure M and subsequent treatment of the crude product according to the general procedure N. Obtained as a light yellow solid (126 mg).

Sources & evidence

ORD record
ord-6c5916d5d7ed46df8e7b760710e9f827
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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