Trifluoroacetic acid → HCID 22317962, compound

HRID 498815Notes

Reaction equation

HRID 498815 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=1[NH:18][C:19](=[O:39])[CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]2[CH:30]=[N:31][C:32]([CH:36]3[CH2:38][CH2:37]3)=[CH:33][C:34]=2[CH3:35])[CH:24]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:36]1([C:32]2[N:31]=[CH:30][C:29]([C:25]3[CH:24]=[C:23]([C:21]4[CH2:20][C:19](=[O:39])[NH:18][C:9]5[CH:10]=[C:11]([C:14]([F:17])([F:16])[F:15])[CH:12]=[CH:13][C:8]=5[N:7]=4)[CH:28]=[CH:27][CH:26]=3)=[C:34]([CH3:35])[CH:33]=2)[CH2:38][CH2:37]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589443HCID 86589443, compound

Product 1

HCID 22317962HCID 22317962, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-[3-(6-cyclopropyl-4-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M264) (260 mg, 0.47 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (67 mg, 33%).

Sources & evidence

ORD record
ord-187beddba1c7427e958be423d1645be2
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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