Trifluoroacetic acid → HCID 22317987, compound

HRID 498820Notes

Reaction equation

HRID 498820 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH:14]2[CH2:16][CH2:15]2)[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:39])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:37]=[CH:36][N:35]=[C:34]([CH3:38])[CH:33]=2)[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:14]1([C:12]2[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]3[NH:21][C:22](=[O:39])[CH2:23][C:24]([C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([C:32]5[CH:37]=[CH:36][N:35]=[C:34]([CH3:38])[CH:33]=5)[CH:27]=4)=[N:7][C:8]=3[CH:13]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589449(5-Cyclopropyl-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 22317987HCID 22317987, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (5-cyclopropyl-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M270) (349 mg, 0.63 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (91 mg, 33%).

Sources & evidence

ORD record
ord-866f5882cb8a44fdbac1056b6fe9a5d0
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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