Trifluoroacetic acid → HCID 22317481, compound

HRID 498832Notes

Reaction equation

HRID 498832 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:18])[CH2:15][CH2:16][CH3:17])[C:11]([C:19]([F:22])([F:21])[F:20])=[CH:10][C:9]=1[NH:23][C:24](=[O:48])[CH2:25][C:26](=O)[C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[CH:38]=[CH:37][N:36]=[C:35]([CH2:39][O:40]C3CCCCO3)[CH:34]=2)[CH:28]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:40][CH2:39][C:35]1[CH:34]=[C:33]([C:29]2[CH:28]=[C:27]([C:26]3[CH2:25][C:24](=[O:48])[NH:23][C:9]4[CH:10]=[C:11]([C:19]([F:21])([F:20])[F:22])[C:12]([N:14]([CH3:18])[CH2:15][CH2:16][CH3:17])=[CH:13][C:8]=4[N:7]=3)[CH:32]=[CH:31][CH:30]=2)[CH:38]=[CH:37][N:36]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589500HCID 86589500, compound

Product 1

HCID 22317481HCID 22317481, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (RS)-[5-(methyl-propyl-amino)-2-(3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M282) (0.25 g, 0.36 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light brown solid (109 mg, 62%).

Sources & evidence

ORD record
ord-6273cda323494ec3b56cdd4b32ecdea6
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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