Trifluoroacetic acid → HCID 22317899, compound

HRID 498840Notes

Reaction equation

HRID 498840 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:44])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:37]=[CH:36][N:35]=[C:34]([N:38]3[CH2:43][CH2:42][O:41][CH2:40][CH2:39]3)[CH:33]=2)[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:15]([O:14][C:12]1[C:11]([C:17]([F:20])([F:18])[F:19])=[CH:10][C:9]2[NH:21][C:22](=[O:44])[CH2:23][C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]4[CH:37]=[CH:36][N:35]=[C:34]([N:38]5[CH2:43][CH2:42][O:41][CH2:40][CH2:39]5)[CH:33]=4)[CH:27]=3)=[N:7][C:8]=2[CH:13]=1)[CH3:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589456HCID 86589456, compound

Product 1

HCID 22317899HCID 22317899, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (5-ethoxy-2-{3-[3-(2-morpholin-4-yl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M287) (249 mg, 0.397 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a white solid (162 mg, 80%).

Sources & evidence

ORD record
ord-0a357c2d41e54e6085e3b5d51ddf206c
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

Loading…