Trifluoroacetic acid → HCID 22317936, compound

HRID 498841Notes

Reaction equation

HRID 498841 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15]C(F)(F)F)[C:11](C(F)(F)F)=[CH:10][C:9]=1[NH:24][C:25](=[O:47])[CH2:26][C:27]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([C:35]2[CH:40]=[CH:39][N:38]=[C:37]([N:41]3[CH2:46][CH2:45][O:44][CH2:43][CH2:42]3)[CH:36]=2)[CH:30]=1)=O)(C)(C)C.C(O)([C:51]([F:54])([F:53])[F:52])=O>C(Cl)Cl>[N:41]1([C:37]2[CH:36]=[C:35]([C:31]3[CH:30]=[C:29]([C:27]4[CH2:26][C:25](=[O:47])[NH:24][C:9]5[CH:10]=[C:11]([C:51]([F:54])([F:53])[F:52])[C:12]([O:14][CH2:15][C:51]([F:54])([F:53])[F:52])=[CH:13][C:8]=5[N:7]=4)[CH:34]=[CH:33][CH:32]=3)[CH:40]=[CH:39][N:38]=2)[CH2:46][CH2:45][O:44][CH2:43][CH2:42]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589457HCID 86589457, compound

Product 1

HCID 22317936HCID 22317936, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2-{3-[3-(2-morpholin-4-yl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M288) (423 mg, 0.62 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light brown solid (214 mg, 61%).

Sources & evidence

ORD record
ord-f774ed801c6c4fd9b05264e7017dacaf
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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