Trifluoroacetic acid → HCID 22317860, compound

HRID 498843Notes

Reaction equation

HRID 498843 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=1[NH:18][C:19](=[O:40])[CH2:20][C:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]2[CH:33]=[CH:32][N:31]=[C:30]([N:34]3[CH2:38][CH2:37][CH2:36][CH2:35]3)[CH:29]=2)[CH:23]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:34]1([C:30]2[CH:29]=[C:28]([C:24]3[CH:23]=[C:22]([C:21]4[CH2:20][C:19](=[O:40])[NH:18][C:9]5[CH:10]=[C:11]([C:14]([F:17])([F:15])[F:16])[CH:12]=[CH:13][C:8]=5[N:7]=4)[CH:27]=[CH:26][CH:25]=3)[CH:33]=[CH:32][N:31]=2)[CH2:35][CH2:36][CH2:37][CH2:38]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589459(2-{3-Oxo-3-[3-(2-pyrrolidin-1-yl-pyridin-4-yl)-phenyl]-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 22317860HCID 22317860, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-{3-oxo-3-[3-(2-pyrrolidin-1-yl-pyridin-4-yl)-phenyl]-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M290) (294 mg, 0.52 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (191 mg, 82%).

Sources & evidence

ORD record
ord-856a8fabdf034e4094ad55f76f734230
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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