HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-[2,3']Bipyridinyl-4-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | [2-(3-[2,3']Bipyridinyl-4-yl-3-oxo-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester | HCID 86589463 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[2,3']Bipyridinyl-4-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 22317400 | — |
Reaction Steps
The title compound was prepared from [2-(3-[2,3′]bipyridinyl-4-yl-3-oxo-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M294) (230 mg, 0.46 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (147 mg, 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-7ec00d1b94b44164b3ed5d140162c3a1 |
| Source note | uspto-grants-2005_09 |