Trifluoroacetic acid → 4-[2,3']Bipyridinyl-4-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 498847Notes

Reaction equation

HRID 498847 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=1[NH:18][C:19](=[O:35])[CH2:20][C:21]([C:23]1[CH:28]=[CH:27][N:26]=[C:25]([C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)[CH:24]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:26]1[CH:27]=[CH:28][C:23]([C:21]2[CH2:20][C:19](=[O:35])[NH:18][C:9]3[CH:10]=[C:11]([C:14]([F:17])([F:16])[F:15])[CH:12]=[CH:13][C:8]=3[N:7]=2)=[CH:24][C:25]=1[C:29]1[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589463[2-(3-[2,3']Bipyridinyl-4-yl-3-oxo-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

Product 1

HCID 223174004-[2,3']Bipyridinyl-4-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2-(3-[2,3′]bipyridinyl-4-yl-3-oxo-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M294) (230 mg, 0.46 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (147 mg, 84%).

Sources & evidence

ORD record
ord-7ec00d1b94b44164b3ed5d140162c3a1
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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