Trifluoroacetic acid → HCID 22317801, compound

HRID 498848Notes

Reaction equation

HRID 498848 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:38])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][N:29]=[C:28]([C:32]2[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=2)[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:29]1[CH:30]=[CH:31][C:26]([C:24]2[CH2:23][C:22](=[O:38])[NH:21][C:9]3[CH:10]=[C:11]([C:17]([F:20])([F:19])[F:18])[C:12]([O:14][CH2:15][CH3:16])=[CH:13][C:8]=3[N:7]=2)=[CH:27][C:28]=1[C:32]1[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589464[2-(3-[2,3']Bipyridinyl-4-yl-3-oxo-propionylamino)-5-ethoxy-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

Product 1

HCID 22317801HCID 22317801, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2-(3-[2,3′]bipyridinyl-4-yl-3-oxo-propionylamino)-5-ethoxy-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M295) (288 mg, 0.53 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (195 mg, 86%).

Sources & evidence

ORD record
ord-437893647a2648578a5445ff86f0fa3c
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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