HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → HCID 22317998, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | N-Methylisobutylamine | HCID 12249 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 22317902 | HCID 22317902 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22317998 | HCID 22317998 | — |
Reaction Steps
The title compound was prepared from 4-[3-(2-hydroxymethyl-pyridin-4-yl)-phenyl]-7-(isobutyl-methyl-amino)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one (Example 366) (248 mg, 0.50 mmol) by reaction with thionylchloride in CH2Cl2 and subsequent treatment of the corresponding crude chloride with isobutyl-methyl-amine in DMF according to the general procedure of Example 288. Obtained as an off-white solid (176 mg, 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-4b414ae4a6e54fc897796c11c94cffbc |
| Source note | uspto-grants-2005_09 |