Trifluoroacetic acid → HCID 22317720, compound

HRID 498861Notes

Reaction equation

HRID 498861 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])C(C(F)(F)F)=[CH:10][C:9]=1[NH:21][C:22](=[O:47])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:37]=[C:36]([CH2:38][O:39]C3CCCCO3)[N:35]=[C:34]([CH3:46])[CH:33]=2)[CH:27]=1)=O)(C)(C)C.[C:49](O)([C:51]([F:54])([F:53])[F:52])=O>C(Cl)Cl>[CH2:15]([O:14][C:12]1[C:49]([C:51]([F:54])([F:53])[F:52])=[CH:10][C:9]2[NH:21][C:22](=[O:47])[CH2:23][C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]4[CH:33]=[C:34]([CH3:46])[N:35]=[C:36]([CH2:38][OH:39])[CH:37]=4)[CH:27]=3)=[N:7][C:8]=2[CH:13]=1)[CH3:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589468HCID 86589468, compound

Product 1

HCID 22317720HCID 22317720, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (RS)-[5-ethoxy-2-(3-{3-[2-methyl-6-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-3-oxo-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M301) (0.54 g, 0.80 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light red solid (240 mg, 64%).

Sources & evidence

ORD record
ord-088fb64efb024c5988dbcf27b906fc08
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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