Trifluoroacetic acid → HCID 22317740, compound

HRID 498862Notes

Reaction equation

HRID 498862 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=1[NH:18][C:19](=[O:44])[CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]2[CH:34]=[C:33]([CH2:35][O:36]C3CCCCO3)[N:32]=[C:31]([CH3:43])[CH:30]=2)[CH:24]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:36][CH2:35][C:33]1[CH:34]=[C:29]([C:25]2[CH:24]=[C:23]([C:21]3[CH2:20][C:19](=[O:44])[NH:18][C:9]4[CH:10]=[C:11]([C:14]([F:17])([F:15])[F:16])[CH:12]=[CH:13][C:8]=4[N:7]=3)[CH:28]=[CH:27][CH:26]=2)[CH:30]=[C:31]([CH3:43])[N:32]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589469(RS)-[2-(3-{3-[2-Methyl-6-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-3-oxo-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

Product 1

HCID 22317740HCID 22317740, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (RS)-[2-(3-{3-[2-methyl-6-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-3-oxo-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M302) (0.46 g, 0.73 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (210 mg, 67%).

Sources & evidence

ORD record
ord-7ee7801061424a51b68aff055b94eab7
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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