HCID 68458312, compound → HCID 68457867, compound

HRID 499073Notes

Reaction equation

HRID 499073 reaction equation
[ClH:1].C([N:15]1[CH2:18][C:17]([O:20][CH:21]([CH3:23])[CH3:22])([CH3:19])[CH2:16]1)(C1C=CC=CC=1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[ClH:1].[CH:21]([O:20][C:17]1([CH3:19])[CH2:18][NH:15][CH2:16]1)([CH3:23])[CH3:22]

Participants

4

Reactant 1

HCID 68458312HCID 68458312, compound

Product 1

HCID 68457867HCID 68457867, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

To a slurry of 1-benzhydryl-3-isopropoxy-3-methylazetidine hydrochloride (1.23 g, 3.71 mmol) in ethanol (30 ml) was added 10% Palladium hydroxide on carbon (200 mg) and the mixture degassed three times with nitrogen and three times with hydrogen. The mixture was then stirred under a hydrogen atmosphere at room temperature for a 12 h. The reaction was degassed with nitrogen and filtered through celite and concentrated. The compound was used crude in subsequent chemistry.

Workup

  1. customthe mixture degassed three times with nitrogen and three times with hydrogen
  2. customThe reaction was degassed with nitrogen
  3. filtrationfiltered through celite
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-95092e9a655e48168ffdf64911e22e48
Source dataset
uspto-grants-2010_08
Patent number
US07767672B2

Reaction notes

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