反应详情

To a solution of 3-chloro-6-phenylpyridazine (0.960 g, 5.000 mmol) in acetonitrile (25 mL) was added piperazine (2.580 g, 30.00 mmol) and the mixture was stirred at reflux for 16 hours. The solvent was removed in vacuo and the residue was dissolved in dichloromethane. The resulting solution was washed with water, dried over MgSO4 and concentrated. The title compound was obtained in 99% yield (1.200 g).

1. temperatureat reflux for 16 hours
2. customThe solvent was removed in vacuo
3. dissolutionthe residue was dissolved in dichloromethane
4. washThe resulting solution was washed with water
5. dry with materialdried over MgSO4
6. concentrationconcentrated