HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 499156Generated: October 30, 2026
Piperazine → 2-(6-Piperazin-1-YL-pyridin-3-YL)-1H-benzoimidazole
https://huagongshe.com/reaction/499156
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-(6-chloropyridin-3-yl)-1H-1,3-benzodiazole | HCID 1488390 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-(6-Piperazin-1-YL-pyridin-3-YL)-1H-benzoimidazole | HCID 67523232 | 93% |
Reaction Steps
A mixture of 2-(6-chloropyridin-3-yl)-1H-benzoimidazole (0.468 g, 2.040 mmol) and piperazine (0.516 g, 6.000 mmol) in 1-methyl-2-pyrrolidone was heated to 140° C. with stirring for 2 hours. The solvent was removed in vacuo. The residue was diluted with water (100 mL) and stirred for 15 minutes. A white precipitate was formed which was collected by filtration and dried to afford the title compound in 93% yield (0.529 g, 1.900 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07767677B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-dc0cb6459b17461a832638e28ded9bcc |
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| Source note | uspto-grants-2010_08 |
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