反应详情

温度

140 °C

A mixture of 2-(6-chloropyridin-3-yl)-1H-benzoimidazole (0.468 g, 2.040 mmol) and piperazine (0.516 g, 6.000 mmol) in 1-methyl-2-pyrrolidone was heated to 140° C. with stirring for 2 hours. The solvent was removed in vacuo. The residue was diluted with water (100 mL) and stirred for 15 minutes. A white precipitate was formed which was collected by filtration and dried to afford the title compound in 93% yield (0.529 g, 1.900 mmol).

1. customThe solvent was removed in vacuo
2. additionThe residue was diluted with water (100 mL)
3. stirringstirred for 15 minutes
4. customA white precipitate was formed which
5. filtrationwas collected by filtration
6. customdried