反应详情

温度

160 °C

A mixture of 6-chloropyridazine-3-carboxylic acid (0.800 g, 5.060 mmol), o-phenylenediamine (0.550 g, 5.080 mmol) amd polyphosphoric acid (25 g) was heated at 150-170° C. with stirring for 3 hours. Water was added to the reaction mixture, and the resulting solution was neutralized with NaHCO3, and extracted with ethyl acetate. The organic phase was dried and evaporated to afford 6-(1H-benzoimidazol-2-yl)pyridazin-3-ol was isolated as a white solid in 31% yield (0.322 g, 1.570 mmol).

1. extractionextracted with ethyl acetate
2. customThe organic phase was dried
3. customevaporated