反应详情

温度

22 °C

The above white solid, {4-[1-(2,6-dichloro-benzoyl)-piperidin-4-yloxy]-phenyl}-carbamic acid tert-butyl ester, is suspended in a solution of trifluoroacetic acid in dichloromethane (25% v/v, 20 mL). The reaction mixture is stirred at 22° C. for 15 min. After removal of the solvent, the oily residue is neutralized with 0.5 N aqueous sodium hydroxide solution (50 mL) and extracted with dichloromethane (5×50 mL). The combined organic phases are dried over anhydrous sodium sulfate and concentrated to yield a yellow solid (440.2 mg, 92.0% yield, ES+(m/z) 365.1 [M+H]).

1. customAfter removal of the solvent
2. extractionextracted with dichloromethane (5×50 mL)
3. dry with materialThe combined organic phases are dried over anhydrous sodium sulfate
4. concentrationconcentrated
5. customto yield a yellow solid (440.2 mg, 92.0% yield, ES+(m/z) 365.1 [M+H])