反应详情

温度

22 °C

To a solution of 4-[2-(dimethylamino)-ethoxy]-benzoic acid methyl ester (3 mmol) in methanol (10 mL) is added a lithium hydroxide solution (2 M, 20 mL). The reaction mixture is stirred at 22° C. for 15 min. After removal of the solvent, the residue is re-dissolved in methanol, passed through a SCX column, washed with methanol, and eluded with 2M ammonia in methanol. After solvent is evaporated, a white solid is obtained (500 mg, 80% yield, ES−(m/z) 208.2 [M−H]).

1. customAfter removal of the solvent
2. dissolutionthe residue is re-dissolved in methanol
3. washwashed with methanol
4. customAfter solvent is evaporated
5. customa white solid is obtained (500 mg, 80% yield, ES−(m/z) 208.2 [M−H])