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0 °C

To an ice-cooled solution of 4-(3-aminophenyl)-piperidine hydrochloride (250.2 mg, 1.0 mmol) and triethylamine (1 mL) in dichloromethane (6 mL) is added 2,6-dichlorobenzoic chloride (0.15 mL, 1.0 mmol). The reaction mixture is stirred at 0° C. for 6 hours. After removal of solvent, the residue is purified on a silica gel chromatography with ethyl acetate-hexanes to provide a white solid (163.9 mg, 46.9% yield, ES+(m/z) 349.1 [M+H]).

1. customAfter removal of solvent
2. customthe residue is purified on a silica gel chromatography with ethyl acetate-hexanes
3. customto provide a white solid (163.9 mg, 46.9% yield, ES+(m/z) 349.1 [M+H])