HRID499203
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 22 °C
PROCEDURE
实验过程
To an ice-cooled solution of 1-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-3-[4-(piperidin-4-yloxy)-phenyl]-urea (82.2 mg, 0.22 mmol), 1-hydroxybenzotriazole (HOBt, 50.1 mg, 0.37 mmol), and benzoic acid (38.8 mg, 0.32 mmol) in dichloromethane-THF (1:1, 2 mL) is added DCC (52.0 mg, 0.25 mmol). The reaction mixture is stirred at 22° C. for 19 hours. The crude product is purified on a silica gel chromatography with ethyl acetate-hexanes to provide a white solid (97.7 mg, 93.4% yield, ES+(m/z) 476.1 [M+H]).
WORKUP
后处理
- customThe crude product is purified on a silica gel chromatography with ethyl acetate-hexanes
- customto provide a white solid (97.7 mg, 93.4% yield, ES+(m/z) 476.1 [M+H])