Hydrochloric Acid → HCID 68830411, compound

HRID 49921Notes

Reaction equation

HRID 49921 reaction equation
[C:1]([NH:4][C:5](=[CH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][C:12]=1[O:19][CH2:20][CH2:21][NH:22]C(OC(C)(C)C)=O)[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2].[ClH:30]>O1CCOCC1>[ClH:30].[C:1]([NH:4][C:5](=[CH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][C:12]=1[O:19][CH2:20][CH2:21][NH2:22])[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68833044Methyl 2-Acetamido-3-[2-(2-(t-butoxycarbonylamino)ethoxy)-4-cyanophenyl]acrylate

Product 1

HCID 68830411HCID 68830411, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

30 ml of dioxane was added to 7.75 g (19.2 mmol) of methyl 2-acetamido-3-[2-(2-t-butoxycarbonylamino-ethoxy)-4-cyanophenyl]-acrylate, and they were stirred. 80 ml of dioxane containing 4 M of hydrogen chloride was added to the obtained mixture, and they were stirred at room temperature for 1 hour. The solvent was evaporated, and the residue was suspended in ethyl acetate. The title compound was obtained by the filtration.

Workup

  1. stirringwere stirred at room temperature for 1 hour
  2. customThe solvent was evaporated

Sources & evidence

ORD record
ord-43c0a1672f314ad8bb1c18a0ff5c6a8c
Source dataset
uspto-grants-2004_03
Patent number
US06710056B2

Reaction notes

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