反应详情

30 g of TFA are added to a solution of 9.2 g of the compound obtained in step 4.1, in 85 ml of DCM. The medium is stirred at AT for 5 h, and then concentrated. The crude obtained is taken up in DCM and then washed 4 times with a 2M sodium hydroxide solution. The organic phase is washed with a saturated NaCl solution. After drying over MgSO4, the organic phase is concentrated, to give 6.32 g of the expected product.

1. concentrationconcentrated
2. customThe crude obtained
3. washwashed 4 times with a 2M sodium hydroxide solution
4. washThe organic phase is washed with a saturated NaCl solution
5. dry with materialAfter drying over MgSO4
6. concentrationthe organic phase is concentrated