HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 4-(1-Methylpiperidine-2-carbonyl)piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | Tert-butyl 4-(piperidine-2-carbonyl)piperazine-1-carboxylate | HCID 50986447 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(1-Methylpiperidine-2-carbonyl)piperazine-1-carboxylic acid tert-butyl ester | HCID 68457637 | — |
Reaction Steps
0.54 ml of 37% aqueous formaldehyde and then 1.41 g of NaBH(OAc)3 are added to a solution of 0.99 g of the compound obtained in step 5.2, in 11 ml of DCE, and the medium is stirred at AT for 12 h. The medium is diluted in DCM and filtered through cotton wool. The organic phase is washed twice with a saturated NaHCO3 solution, and then with a saturated NaCl solution. After drying over MgSO4 and evaporation of the solvents, 0.84 g of the expected product is recovered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07767681B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-ec7eb7b3d6d14b7b83d53b22e33afc3f |
| Source note | uspto-grants-2010_08 |