反应详情

0.54 ml of 37% aqueous formaldehyde and then 1.41 g of NaBH(OAc)3 are added to a solution of 0.99 g of the compound obtained in step 5.2, in 11 ml of DCE, and the medium is stirred at AT for 12 h. The medium is diluted in DCM and filtered through cotton wool. The organic phase is washed twice with a saturated NaHCO3 solution, and then with a saturated NaCl solution. After drying over MgSO4 and evaporation of the solvents, 0.84 g of the expected product is recovered.

1. filtrationfiltered through cotton wool
2. washThe organic phase is washed twice with a saturated NaHCO3 solution
3. dry with materialAfter drying over MgSO4 and evaporation of the solvents, 0.84 g of the expected product
4. customis recovered