HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (1-Methylpiperidin-2-yl)piperazin-1-ylmethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-(1-Methylpiperidine-2-carbonyl)piperazine-1-carboxylic acid tert-butyl ester | HCID 68457637 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (1-Methylpiperidin-2-yl)piperazin-1-ylmethanone | HCID 68458326 | 26.3% |
Reaction Steps
2 ml of TFA are added to a solution of 0.84 g of the compound obtained in step 5.3, in 2 ml of DCM. The medium is stirred at AT for 6 h. The medium is evaporated, taken up several times in DCM, and evaporated so as to entrain the TFA. The medium is taken up in DCM and then treated with a 10% NH4OH solution. The organic phase is dried over MgSO4 and then evaporated, to give 0.15 g of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07767681B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-0834ac3fee5d42198a5a63a47cef7077 |
| Source note | uspto-grants-2010_08 |