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HRID499235

反应详情

EQUATION

反应方程式

HRID 499235 的结构方程式

REACTANTS

反应物

2
结构：COC(OC)N(C)C
HCID78373

Methanamine, 1,1-dimethoxy-N,N-dimethyl-

C5H13NO2

结构：CCOC(=O)CC(=O)c1ccccc1F
HCID296342

ethyl 3-(2-fluorophenyl)-3-oxopropanoate

C11H11FO3

PRODUCTS

生成物

1
结构：CCOC(=O)C(=CN(C)C)C(=O)c1ccccc1F
HCID54124074

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A mixture of ethyl 3-(2-fluorophenyl)-3-oxopropanoate (14.29 g, 68.0 mmol) and DMF-DMA (12.15 g, 0.102 mol, 1.5 eq.) in toluene (50 mL) was refluxed for 2 hours and concentrated to give 3-dimethylamino-2-(2-fluoro-benzoyl)-acrylic acid ethyl ester as a red oil in quantitative yield.

WORKUP

后处理

  1. temperaturewas refluxed for 2 hours
  2. concentrationconcentrated