HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 2-Acetamido-3-[2-[(2R)-4-benzyloxycarbonyl-2-aminobutoxy]-4-cyanophenyl]acrylate Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 2-Acetamido-3-[2-[(2R)-4-benzyloxycarbonyl-2-(t-butoxycarbonylamino)butoxy]-4-cyanophenyl]acrylate | HCID 69143806 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Methyl 2-Acetamido-3-[2-[(2R)-4-benzyloxycarbonyl-2-aminobutoxy]-4-cyanophenyl]acrylate Hydrochloride | HCID 69143123 | — |
Reaction Steps
5 g of methyl 2-acetamido-3-[2-[(2R)-4-benzyloxycarbonyl-2-(t-butoxycarbonylamino)butoxy]-4-cyanophenyl]acrylate was stirred in 50 ml of dioxane containing 4 M of hydrogen chloride for 2 hours. The solvent was evaporated to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710056B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-7589d30072554d618009ff6756a2a2d2 |
| Source note | uspto-grants-2004_03 |