Hydrochloric Acid → Methyl 2-Acetamido-3-[2-[(2R)-4-benzyloxycarbonyl-2-aminobutoxy]-4-cyanophenyl]acrylate Hydrochloride

HRID 49925Notes

Reaction equation

HRID 49925 reaction equation
[C:1]([NH:4][C:5](=[CH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][C:12]=1[O:19][CH2:20][C@H:21]([NH:34]C(OC(C)(C)C)=O)[CH2:22][CH2:23][C:24]([O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:25])[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2].[ClH:42]>O1CCOCC1>[ClH:42].[C:1]([NH:4][C:5](=[CH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][C:12]=1[O:19][CH2:20][C@H:21]([NH2:34])[CH2:22][CH2:23][C:24]([O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:25])[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69143806Methyl 2-Acetamido-3-[2-[(2R)-4-benzyloxycarbonyl-2-(t-butoxycarbonylamino)butoxy]-4-cyanophenyl]acrylate

Product 1

HCID 69143123Methyl 2-Acetamido-3-[2-[(2R)-4-benzyloxycarbonyl-2-aminobutoxy]-4-cyanophenyl]acrylate Hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5 g of methyl 2-acetamido-3-[2-[(2R)-4-benzyloxycarbonyl-2-(t-butoxycarbonylamino)butoxy]-4-cyanophenyl]acrylate was stirred in 50 ml of dioxane containing 4 M of hydrogen chloride for 2 hours. The solvent was evaporated to obtain the title compound.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-7589d30072554d618009ff6756a2a2d2
Source dataset
uspto-grants-2004_03
Patent number
US06710056B2

Reaction notes

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