HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(2-Furyl)-4H-1,3-benzothiazine-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| Reactant | 2-Furonitrile | HCID 69245 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(2-Furyl)-4H-1,3-benzothiazine-4-one | HCID 59750444 | 19% |
Reaction Steps
A mixture of methyl thiosalicylate (1.01 g, 6.0 mmol), 2-furonitrile (0.57 g, 6.0 mmol), triethylamine (1.5 ml, 10.7 mmol) and toluene (20 ml) was refluxed for 24 hrs. After cooling, the precipitated crystals were collected by filtration and recrystallized from hexane-ethanol to give the titled compound (0.26 g, 19%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07767665B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-60611f7348c24b33aee5bdf878a0b727 |
| Source note | uspto-grants-2010_08 |