Pyridine-2-carbonitrile → HCID 59750441, compound

HRID 499276Notes

Reaction equation

HRID 499276 reaction equation
[SH:1][C:2]1[C:10]([CH3:11])=[CH:9][C:8]([CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)#[N:14]>N1C=CC=CC=1>[CH3:12][C:8]1[CH:9]=[C:10]([CH3:11])[C:2]2[S:1][C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)=[N:14][C:4](=[O:6])[C:3]=2[CH:7]=1

Participants

4

Reactant 2

HCID 7522Pyridine-2-carbonitrileHCID 22939285HCID 22939285, compound

Product 1

HCID 59750441HCID 59750441, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 2-mercapto-3,5-dimethylbenzoic acid (1.6 g, 8.8 mmol), 2-cyanopyridine (1.0 g, 9.7 mmol) and pyridine (15 ml) was refluxed for 12 hrs as described in Example 9. After cooling, the precipitated crystals were collected by filtration and recrystallized from hexane-chlorobenzene to give the titled compound (1.2 g, 52%)

Workup

  1. temperaturewas refluxed for 12 hrs
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were collected by filtration
  4. customrecrystallized from hexane-chlorobenzene

Sources & evidence

ORD record
ord-f8de95d7e3764b8ebff9638e541a218a
Source dataset
uspto-grants-2010_08
Patent number
US07767665B2

Reaction notes

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