HCID 68458787, compound → HCID 59750280, compound

HRID 499350Notes

Reaction equation

HRID 499350 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5][C:4]([C:12]2[CH:17]=[C:16]([CH2:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][C:24]([O:26]C(C)(C)C)=[O:25])[CH:15]=[CH:14][N:13]=2)=[N:3]1>FC(F)(F)C(O)=O>[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5][C:4]([C:12]2[CH:17]=[C:16]([CH2:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])[CH:15]=[CH:14][N:13]=2)=[N:3]1

Participants

3

Reactant 1

HCID 68458787HCID 68458787, compound

Product 1

HCID 59750280HCID 59750280, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of tert-butyl 3-[3-[2-(4-oxo-4H-1,3-benzothiazin-2-yl)-4-pyridyl]propoxy]propanoate (3.9 g, 9.1 mmol) and trifluoroacetic acid (30 ml) was stirred at room temperature for 1.5 hrs. The reaction mixture was concentrated under reduced pressure to obtain crystals which were collected by filtration and recrystallized from chloroform to give the titled compound (3.0 g, 89%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto obtain crystals which
  3. filtrationwere collected by filtration
  4. customrecrystallized from chloroform

Sources & evidence

ORD record
ord-f2fea512b5284e869c15d353fbf944ba
Source dataset
uspto-grants-2010_08
Patent number
US07767665B2

Reaction notes

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