Trifluoroacetic acid → HCID 22939297, compound

HRID 499353Notes

Reaction equation

HRID 499353 reaction equation
[CH3:1][N:2]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]2[S:17][C:18]3[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=3[C:20](=[O:22])[N:21]=2)[N:11]=1)C(=O)OC(C)(C)C.FC(F)(F)C(O)=O>>[CH3:1][NH:2][C:10]1[N:11]=[C:12]([C:16]2[S:17][C:18]3[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=3[C:20](=[O:22])[N:21]=2)[CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59750257tert-butyl methyl[6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]carbamate

Product 1

HCID 22939297HCID 22939297, compoundYield 76.6%

Procedure

A mixture of tert-butyl methyl[6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]carbamate (0.60 g, 1.6 mmol) and trifluoroacetic acid (8 ml) was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure to give crystals, which were recrystallized from methanol-diethyl ether to give the titled compound (0.33 g, 74%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto give crystals, which
  3. customwere recrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-7067705e4695415f9c223d5ae2d31a09
Source dataset
uspto-grants-2010_08
Patent number
US07767665B2

Reaction notes

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