反应详情

温度

80 °C

A mixture of 2-(6-methylamino-2-pyridyl)-4H-1,3-benzothiazine-4-one (0.20 g, 0.74 mmol), 2-thiophenecarbonyl chloride (0.28 g, 1.9 mmol) and N,N-dimethylacetamide (10 ml) was stirred at 80° C. for 2 hrs. After cooling, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed successively with saturated aqueous sodium hydrogen carbonate solution and brine and dried. The solvent was evaporated. The residue was recrystallized from tetrahydrofuran-hexane to give the titled compound (0.23 g, 83%).

1. temperatureAfter cooling
2. extractionextracted with ethyl acetate
3. washThe extract was washed successively with saturated aqueous sodium hydrogen carbonate solution and brine
4. customdried
5. customThe solvent was evaporated
6. customThe residue was recrystallized from tetrahydrofuran-hexane