反应详情

温度

80 °C

A mixture of 2-(6-methylamino-2-pyridyl)-4H-1,3-benzothiazine-4-one (0.20 g, 0.74 mmol), 2-furoyl chloride (0.26 g, 2.0 mmol) and N,N-dimethylacetamide (10 ml) was stirred at 80° C. for 2 hrs. After cooling, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed successively with saturated aqueous sodium hydrogen carbonate solution and brine and dried. The solvent was evaporated. The residue was subjected to a silica gel column chromatography and eluted with hexane-ethyl acetate (1:1, v/v). The obtained crystals were recrystallized from ethyl acetate-hexane to give the titled compound (0.21 g, 63%).

1. temperatureAfter cooling
2. extractionextracted with ethyl acetate
3. washThe extract was washed successively with saturated aqueous sodium hydrogen carbonate solution and brine
4. customdried
5. customThe solvent was evaporated
6. washeluted with hexane-ethyl acetate (1:1
7. customThe obtained crystals were recrystallized from ethyl acetate-hexane