Water → 5-Iodo-2-methoxybenzoic acid

HRID 49951Notes

Reaction equation

HRID 49951 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([I:13])=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].O>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([I:13])=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 962WaterHCID 11011762Methyl 5-iodo-2-methoxybenzoate

Product 1

HCID 40861665-Iodo-2-methoxybenzoic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

Methyl 2-Methoxy-5-iodobenzoate obtained in step 1 in Example 27 was stirred in a solvent mixture (10 ml) of water and dioxane containing 4 N hydrogen chloride under heating at 80° C. for 3 hours. The solvent was evaporated to obtain the title compound.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-d4dd423932274b26b287f5bea2bdce86
Source dataset
uspto-grants-2004_03
Patent number
US06710056B2

Reaction notes

Loading…