Lithium Hydroxide → 2-Methoxy-5-(thiophene-2-yl)benzoic acid

HRID 49952Notes

Reaction equation

HRID 49952 reaction equation
[OH-].[Li+].[CH3:3][O:4][C:5]1[CH:14]=[CH:13][C:12]([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8]>C1(C)C=CC=CC=1.C(O)C.O>[CH3:3][O:4][C:5]1[CH:14]=[CH:13][C:12]([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)=[CH:11][C:6]=1[C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 17834378methyl 2-Methoxy-5-(thiophene-2-yl)benzoate

Product 1

HCID 178343472-Methoxy-5-(thiophene-2-yl)benzoic acid

Reagents, catalysts & solvents 1

HCID 86587398Ethanol toluene waterSolvent

Procedure

Lithium hydroxide (43 mg) was added to methyl 2-Methoxy-5-(thiophene-2-yl)benzoate (102 mg) in a solvent mixture of tetrahydrofuran/methanol/water (2/1/1, 3 ml), and they were stirred overnight. The solvent was evaporated, and the residue was added to 3 N hydrochloric acid. The white solid thus precipitated was taken by the filtration as the title compound.

Workup

  1. customThe solvent was evaporated
  2. additionthe residue was added to 3 N hydrochloric acid
  3. customThe white solid thus precipitated
  4. filtrationwas taken by the filtration as the title compound

Sources & evidence

ORD record
ord-6aa0eea50c67435d9f96eab69e230ebb
Source dataset
uspto-grants-2004_03
Patent number
US06710056B2

Reaction notes

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