HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoethyl methyl ether → 4-[Hydroxy(diphenyl)methyl]-1-[2-(methyloxy)ethyl]-1-azoniabicyclo[2.2.1]heptane bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoethyl methyl ether | HCID 80972 | — |
| Reactant | 1-Azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol | HCID 42625856 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[Hydroxy(diphenyl)methyl]-1-[2-(methyloxy)ethyl]-1-azoniabicyclo[2.2.1]heptane bromide | HCID 16041400 | 24.1% |
Reaction Steps
Following the general procedure outlined in Example 1, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol (30.8 mg, 0.110 mmol) and 1-bromo-2-(methyloxy)ethane (0.03 mL, 0.3 mmol) in 2 CH3CN/3 CHCl3 (2.5 nm) were reacted to give the desired product (11.1 mg, 24%). EI-MS m/z 338 (M+) Rt (1.64 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07767691B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-99ad66f05e594a69b9f89b8b68737205 |
| Source note | uspto-grants-2010_08 |