4-Nitrobenzyl bromide → HCID 16041750, compound

HRID 499675Notes

Reaction equation

HRID 499675 reaction equation
[N:1]12[CH2:7][C:4]([C:8]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[OH:9])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:22]C[C:24]1[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][CH:25]=1>CC#N>[Br-:22].[OH:9][C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]12[CH2:7][N+:1]([CH2:3][CH2:4][CH2:8][O:9][C:24]3[CH:25]=[CH:26][C:27]([N+:30]([O-:32])=[O:31])=[CH:28][CH:29]=3)([CH2:6][CH2:5]1)[CH2:2][CH2:3]2

Participants

4

Reactant 2

HCID 660114-Nitrobenzyl bromideHCID 426258561-Azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol

Product 1

HCID 16041750HCID 16041750, compoundYield 101.9%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 2, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol (33.2 mg, 0.119 mmol) and 1-(bromomethyl)-4-nitrobenzene (45.9 mg, 0.176 mmol) in 2 CH3CN/3 CHCl3 (2.5 mL) were reacted to give the desired product (32.7 mg, 51%). EI-MS m/z 459 (M+) Rt (1.83 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-57e07639c1584aeba61feaaf5d1ea75f
Source dataset
uspto-grants-2010_08
Patent number
US07767691B2

Reaction notes

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