(3-Bromo-propoxy)-phenol → HCID 16041752, compound

HRID 499676Notes

Reaction equation

HRID 499676 reaction equation
[N:1]12[CH2:7][C:4]([C:8]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[OH:9])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:22][CH2:23][CH2:24][CH2:25][O:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[OH:33]>CC#N>[Br-:22].[OH:9][C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]12[CH2:7][N+:1]([CH2:23][CH2:24][CH2:25][O:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[OH:33])([CH2:6][CH2:5]1)[CH2:2][CH2:3]2

Participants

4

Reactant 2

HCID 13197597(3-Bromo-propoxy)-phenolHCID 426258561-Azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol

Product 1

HCID 16041752HCID 16041752, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 2, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol (30.9 mg, 0.111 mmol) and 2-[(3-bromopropyl)oxy]phenol (47.9 mg, 0.207 mmol) in 2 CH3CN/3 CHCl3 (2.5 mL) were reacted to give the desired product (20.9 mg, 37%). EI-MS m/z 430 (M+) Rt (1.70 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-206e802366104acfb024a3b3b52c4311
Source dataset
uspto-grants-2010_08
Patent number
US07767691B2

Reaction notes

Loading…