1-(3-Bromopropoxy)-3-chlorobenzene → HCID 16041756, compound

HRID 499678Notes

Reaction equation

HRID 499678 reaction equation
[N:1]12[CH2:7][C:4]([C:8]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[OH:9])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Cl:22][C:23]1[CH:24]=[C:25]([O:29][CH2:30][CH2:31][CH2:32][Br:33])[CH:26]=[CH:27][CH:28]=1>CC#N>[Br-:33].[Cl:22][C:23]1[CH:24]=[C:25]([O:29][CH2:30][CH2:31][CH2:32][N+:1]23[CH2:7][C:4]([C:8]([OH:9])([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=4)([CH2:5][CH2:6]2)[CH2:3][CH2:2]3)[CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 27349291-(3-Bromopropoxy)-3-chlorobenzeneHCID 426258561-Azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol

Product 1

HCID 16041756HCID 16041756, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 2, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)methanol (31.9 mg, 0.114 mmol) and 3-bromopropyl 3-chlorophenyl ether (50.6 mg, 0.203 mmol) in 2 CH3CN/3 CHCl3 (2.5 mL) were reacted to give the desired product (28.7 mg, 48%). EI-MS m/z 448 (M+) Rt (2.0 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-dbe4f1e1620340a6a0edcb9702740519
Source dataset
uspto-grants-2010_08
Patent number
US07767691B2

Reaction notes

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