3-Bromo-1-propanol → HCID 16042141, compound

HRID 499690Notes

Reaction equation

HRID 499690 reaction equation
[N:1]12[CH2:7][C:4]([C:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:9]#[N:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:23]C[CH2:25][CH2:26][OH:27]>>[Br-:23].[C:9]([C:8]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]12[CH2:7][N+:1]([CH2:25][CH2:26][OH:27])([CH2:6][CH2:5]1)[CH2:2][CH2:3]2)#[N:10]

Participants

3

Reactant 2

HCID 123083-Bromo-1-propanolHCID 42625857HCID 42625857, compound

Product 1

HCID 16042141HCID 16042141, compoundYield 31.2%

Procedure

Following the general procedure outlined in Example 24, 1-azabicyclo[2.2.1]hept-4-yl(diphenyl)acetonitrile (0.044 g, 0.152 mmol) and 3-bromo-1-propanol (0.020 mL, 0.282 mmol) in 2CH3CN/3CHCl3 (3.5 mL) were reacted to give the desired product (0.0196 g, 31.1%). EI-MS m/z 333 (M+) Rt (1.43 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-027b9da24cf84cb597d3f25a49b855be
Source dataset
uspto-grants-2010_08
Patent number
US07767691B2

Reaction notes

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