Nitric Acid → HCID 178470305, compound

HRID 499902Notes

Reaction equation

HRID 499902 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]([O:8][CH2:9][CH3:10])=[O:7].[N+:11]([O-])([OH:13])=[O:12]>S(=O)(=O)(O)O>[N+:11]([C:5]1[N:1]=[C:2]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[NH:3][CH:4]=1)([O-:13])=[O:12]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 549404ethyl 1H-imidazole-2-carboxylate

Product 1

HCID 178470305HCID 178470305, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
55 °C

Procedure

16.08 g (114.7 mmol) of ethyl imidazole-2-carboxylate are dissolved in 71.7 ml of concentrated sulphuric acid while cooling in ice. Then 71.7 ml of 100% strength fuming nitric acid are added dropwise. The reaction solution is stirred at 50 to 60° C. for 3 h and, after cooling, poured into 800 ml of ice/water mixture. The crystals which separate out are filtered off with suction and washed with 1500 ml of ice-water.

Workup

  1. temperaturewhile cooling in ice
  2. temperatureafter cooling
  3. customThe crystals which separate out
  4. filtrationare filtered off with suction
  5. washwashed with 1500 ml of ice-water

Sources & evidence

ORD record
ord-e3f212eb2cb5456a91c663e004cdc4d2
Source dataset
uspto-grants-2010_08
Patent number
US07767704B2

Reaction notes

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