反应详情

温度

55 °C

16.08 g (114.7 mmol) of ethyl imidazole-2-carboxylate are dissolved in 71.7 ml of concentrated sulphuric acid while cooling in ice. Then 71.7 ml of 100% strength fuming nitric acid are added dropwise. The reaction solution is stirred at 50 to 60° C. for 3 h and, after cooling, poured into 800 ml of ice/water mixture. The crystals which separate out are filtered off with suction and washed with 1500 ml of ice-water.

1. temperaturewhile cooling in ice
2. temperatureafter cooling
3. customThe crystals which separate out
4. filtrationare filtered off with suction
5. washwashed with 1500 ml of ice-water