反应详情

1.30 g (3.84 mmol) of ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate (synthesis analogous to Example 4A, stage 3, or else according to Tetrahedron Lett. 2003, 44, 1607 and literature cited therein) are mixed in 50 ml of THF with 1.16 g (7.68 mmol) of 3-fluoro-4-methylphenyl isocyanate under argon and stirred at room temperature overnight. The reaction mixture is filtered, and the filtrate is concentrated in vacuo and purified by preparative HPLC. The residue from filtration affords together with the product obtained after the HPLC purification 715 mg of product.

1. filtrationThe reaction mixture is filtered
2. concentrationthe filtrate is concentrated in vacuo
3. custompurified by preparative HPLC
4. filtrationThe residue from filtration
5. customaffords together with the product
6. customobtained
7. customafter the HPLC purification 715 mg of product